Arsenal and Southampton go head-to-head in the EFL Cup, with a place in the final four of the competition the reward for Wednesday's winners.
The Gunners extended their unbeaten run in all competitions to 19 matches by beating Bournemouth in north London on Sunday and, having gone 24 years without success in this competition, Wenger's men will be determined to maintain momentum when they face the Saints.
As such, Arsenal are chalked up as bet365's 5/6 (1.83) favourites to win inside 90 minutes, while the odds compilers offer just 1/3 (1.34) that it is the north Londoners who reach the semi-final stage by seeing off the Saints.
For Southampton, the wait for success has been even longer; the Saints last lifted a major trophy in 1976 and, despite never having won the League Cup, the side from St Mary's will be in confident mood ahead of this clash, for they are in fine form.
Indeed, Claude Puel's side have been beaten in just two of their last 11 domestic fixtures, conceding just six goals against English opposition during that run of results.
The visitors are considered a 7/2 (4.50) chance to continue their EFL Cup run by beating Arsenal inside normal time, while 9/4 (3.25) is available for Puel's team to secure a semi-final spot at the expense of Wenger's men.
Meanwhile, 29/10 (3.90) is on offer that the tie remains deadlocked at the end of 90 minutes.
Arsenal sank Southampton with the last kick of the game on the previous occasion that these teams met, with Santi Cazorla's last-gasp penalty giving the Gunners all three points in the Premier League and this looks likely to be a similarly tight tussle.
Given that both clubs remain committed to European competition, it would be no real surprise should both Wenger and Puel opt to rest a number of key men for Wednesday's meeting in north London.
Nevertheless, this has all the makings of a tasty tie and punters are advised to take a chance on the chunky even money (2.0) quote for the visitors in bet365's double chance market.
Southampton have been beaten in just two of their previous seven matches against Arsenal, a sequence of results that includes a 2-1 away win for the Saints in this competition in 2014 and the Gunners have been held in three of their last four fixtures in all competitions.
As such, it is bet365's generous even money (2.0) quote for the Saints in the double chance market that carries most appeal ahead of this EFL Cup clash.