Having opened his Premier League account with a hard-fought away victory over West Ham at the weekend, the former Southampton boss in on offer at 4/9 (1.44) with Paddy Power to maintain his winning streak at the Stadio Antonis Papadoulos.
Ivaylo Petev's men have beaten Marseille and Zenit St Petersburg in their previous two European games on home turf but are 13/2 (7.50) outsiders to come out on top here.
Spurs drew 2-2 away to Benfica in their last Europa League fixture and you can get odds of 3/1 (4.00) on them playing out another stalemate in this one.
The last time that the visitors travelled to Limassol was back in 1968, when they recorded a 7-1 victory over the reigning Cypriot champions in a pre-season friendly.
However, the home crowd will be expecting a far more competitive match this time out, with their manager having already promised them "a very good day".
This belief is built on an encouraging display against Zenit in their Champions League qualifier, in which they took a 1-0 lead to Russia for the second leg before having a man sent off after just 25 minutes and eventually losing 3-1 on aggregate.
With the memory of that tie sure to spur them on in Thursday's clash, Pochettino's team will need all of the fighting qualities displayed in the victory at Upton Park, with neither side likely to give anything away.
With this in mind, odds of 8/11 (1.73) offer solid value on no more than one side finding the net, in a bet that would have paid out in 12 of AEL's previous 14 European fixtures.
However, considering Tottenham's extra quality and eagerness to impress under new management, they must be worth backing at 5/4 (2.25) to grind out a victory in a tight encounter.
|'No' on both teams to score for a 2pt stake at 8/11 (1.73) with Paddy Power
||Tottenham to win to nil for a 1pt stake at 5/4 (2.25) with Paddy Power
Sign up with Paddy Power for up to £250 in free bets
Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.