Having beaten these opponents at each of the last two World Cups, the Black Stars are 31/20 (2.55) favourites with bet365 to put themselves in prime position with another victory here.
However, Jurgen Klinsmann's men overcame African champions Nigeria in their final warm-up match and so may feel confident of earning some revenge at odds of 21/10 (3.10).
The previous World Cup encounter at South Africa 2010 was decided in extra time after a draw in 90 minutes and you can get odds of 11/5 (3.20) on the teams cancelling each other out once again here.
While they sealed they place in Brazil courtesy of an emphatic 7-3 aggregate play-off victory over Egypt that included a memorable 6-1 win on home turf, James Kwesi Appiah's men have been far more impressive in defence than up front recently.
Prior to last week's 4-0 friendly victory over South Korea, the African side had scored just five goals in the previous nine games, the last of which were consecutive 1-0 defeats against Montenegro and Netherlands.
This lack of cutting edge is sure to be tested by a resolute American side in Natal, where the forecast of heavy rain is likely to restrict free-flowing football at either end, just as we saw when Cameroon met Mexico in similar conditions at the same stadium on Friday.
With an edgy match looking likely, even money (2.00) quotes are well worth backing on no more than one side finding the net in a bet that would have paid out in five of the Americans' previous eight games and nine of Ghana's last 10.
Should the match finish 0-0 bet365 will refund losing bets on first/last and anytime goalscorer markets as well as half time/full time, correct score and scorecast wagers.
|"No" on Both teams to score for a 1.5pt stake at Evens (2.00) with bet365
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Al Hain-Cole is an experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.