Conceding just after the break, Spurs trailed 2-0 on aggregate, but a free kick from Christian Eriksen and a double from Emmanuel Adebayor sent the North Londoners through to the next round.
Whereas Spurs will be full of confidence, their opponents this weekend will be down in the dumps having lost three of their last four matches.
Cardiff sit second from bottom in the league and the change of manager earlier this season doesn't seem to have help the Bluebirds' cause, as Ole Gunnar Solskjaer has struggled for results.
After Hull City won 4-0 at the Cardiff City Stadium last week, the situation looks bleak for Solskjaer and Cardiff as they desperately need wins. Bet365 price them at 8/1 (9.00) to cause a shock.
Tottenham had lost back-to-back matches before their victory in midweek - losses against Norwich and Dnipro in the first leg put pressure on coach Tim Sherwood, but Europa progress will have done him the world of good.
With Spurs trailing Liverpool by six points in the face for fourth, they can't afford not to take three points from the match this weekend. Bet365 price them at 4/11 (1.36) to win, while the same firm prices a draw at 7/2 (4.50).
With Spurs a little too short to back against a Cardiff City side in dire form, it's worth looking elsewhere for a stand-out price. Tottenham on the -1 handicap at 5/6 (1.83) may be worth backing, but the goalscorer market throws up a better option.
Emmanuel Adebayor has been sensational for Spurs this season and has led the line superbly after being left out at the start of the season. He has netted five goals in his last four matches, and is 10/11 (1.91) to net anytime against Cardiff with bet365. With the striker at the top of his game, expect him to top off a fantastic week with another goal.
|Emmanuel Adebayor to score anytime at 10/11 (1.91) for a 2pt stake with bet365
New bet365 customers can claim a first deposit bonus of up to £200