Rafa Benitez's men bounced back from disappointment at the Stadio Olimpico with a 3-1 home league win over AC Milan on Saturday and are 11/10 (2.10) favourites with bet365 to come out on top.
Meanwhile, the Giallorossi ground out a hard-fought 0-0 draw with Lazio in the Rome derby on Sunday and are available at 12/5 (3.40) to secure a place in their seventh final in 10 seasons with a win.
There has been only one draw in the past eight meetings between these sides but you can get odds of 12/5 (3.40) on them cancelling each other out this time around.
Rudi Garcia's side looked to be well on their way to yet another final after racing into a two-goal lead after half an hour in Rome, only to be pegged back to 2-2 in the second half before Gervinho's late winner.
Despite losing, the Partenopei will now fancy their chances of progressing after grabbing two invaluable away goals, particularly given their strong record in front of their own fans.
November's shock 1-0 defeat to Parma represents not merely the only time that the hosts have lost on home soil this season but also the only time they have failed to find the net at the San Paolo in all competitions.
Having seen his side score 19 goals in eight home games since then, Benitez will be confident that his team's firepower can bring them right back into the tie, particularly with Gonzalo Higuain back on form after hitting his 16th and 17th goals of the season against Milan.
A bet on Napoli to score at least twice would have paid out in 13 of their 17 home games so far this campaign and looks like good value at 10/11 (1.91) when they take on a team defending a dangerously fragile aggregate lead.
That bet looks particularly safe given that Roma have let in at least two goals in recent games against Juventus, AC Milan and Wednesday's opponents.
|Napoli to score over 1.5 goals for a 2pt stake at 10/11 (1.91) with bet365
New bet365 customers can claim a first deposit bonus of up to £200
Al Hain-Cole is an experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.