Rafa Benitez's men sat 10 points off the pace at Christmas after winning just two of their last six Serie A games but are clear 7/20 (1.35) favourites with Betway to get back on track with a first win of 2014.
Sinisa Mihajlovic pulled his side clear of the relegation zone after orchestrating a five-game unbeaten run following his appointment in November and is available at 15/2 (8.50) to endear himself even further with the fans by securing a famous victory in this one.
Three of those five games resulted in draws and you can get odds of 15/4 (4.75) on the Blucerchiati holding their hosts to a stalemate here.
Mihajlovic's impact at the Stadio Luigi Ferraris has been dramatic, taking a team who had lost three consecutive games before his arrival into one who have now gone six games without tasting defeat in all competitions.
The former defender has achieved this largely by tightening things up at the back, transforming a defence that had conceded 21 goals in their opening 12 league games (including four against lowly Sassuolo in predecessor Delio Rossi's last home game in charge) into one that has let in only three in his five games at the helm.
Having frustrated both Lazio and Inter in that period, Sampdoria will be confident of making life difficult for a Partenopei team that have struggled against Sassuolo and Parma in front of their owns fans this campaign, meaning that the strikers could be in for a long 90 minutes.
A bet on under 2.5 goals would have paid out in all five of Mihajlovic's Serie A games in command, so odds of 11/10 (2.10) look extremely generous on no more than two going in when he sets up defensively against Napoli.
|Under 2.5 goals for a 2pt stake at 11/10 (2.10) with Betway
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Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.