The Scots suffered a humiliating 5-1 defeat in Florida when these two sides met back in May 2012 but, following some encouraging results in recent months, the home side will hope for a more positive outcome on this occasion.
Gordon Strachan's men have won three of their last five matches, including home and away victories over World Cup play-off hopefuls Croatia, and the Scots can be backed at 19/10 (2.90) with William Hill to get revenge on Team USA by claiming victory here.
Jurgen Klinsmann's men qualified for World Cup 2014 in comfortable fashion to secure their seventh successive appearance at the finals and the United States can be backed at 6/4 (2.50) with William Hill to emerge victorious. The draw is available at 11/5 (3.20) with the same firm.
It is worth noting that the visitors have lost just one of their last 16 matches, claiming notable friendly victories over Germany and Bosnia-Herzegovina in that time, and the Americans will certainly come into this match in a confident mood.
Sunderland striker Steven Fletcher could lead the line for the hosts and will attract plenty of support at a chunky 6/1 (7.0) with William Hill to break the deadlock. Fletcher's club team-mate, Jozy Altidore, though, could steal the headlines for USA at Hampden.
The 24-year-old American striker was in fine form for Sunderland in their 2-1 win over Southampton in the Capital One Cup and, in the absence of usual talisman Landon Donovan, Altidore will be desperate to make an impact against the Scots.
Altidore is chalked up at a tempting 11/2 (6.50) to score first - a selection that is sure to prove popular with USA backers on Friday.
However, punters should note that more than two goals have been scored in just one of Scotland's last six home matches and another tight encounter seems likely here.
Therefore, the 23/20 (2.15) quote from William Hill for the first goal to arrive after the 30th minute carries appeal while the 11/5 (3.20) on offer from the same firm for the match to end all-square is the recommended play for punters here.
|Draw at 11/5 (3.20) 1pt stake with William Hill
Sign up with William Hill for a £50 free bet
Willie Duncan is a freelance sports journalist. Willie, from Edinburgh, has covered Scottish football for over 10 years and he specialises in football betting markets from across Europe. You can also follow Willie on Twitter
Follow GoalBetting on