Despite suffering defeat in Glasgow, the hosts are chalked up as 4/5 (1.80) favourites with Betway to claim revenge over the Hoops by grabbing a vital victory.
The Hoops will again be without suspended captain Scott Brown for the trip to Amsterdam and can be backed at a chunky 16/5 (4.20) with Betway to pick up all three points here. The draw is available at 13/5 (3.60) with the same firm.
Lennon's men have won just one of their last seven away matches in the Champions League and they will face a stiff test against the Dutch champions.
Both sides still harbour hopes of advancing to the Champions League knockout stages and, with so much at stake, nerves are likely to play a part.
Therefore, the 21/20 (2.05) quote from Betway for fewer than three goals to be scored on Wednesday night represents decent value.
Seven of the nine goals that have featured in Ajax's three Champions League group games have come in the second half, while five of the six goals in Celtic's group matches also came after the interval, so the stage seems to be set for late drama on Wednesday.
The 11/10 (2.10) quote from Betway for the second half to be the highest scoring is worthy of consideration while the 21/20 (2.05) on offer from the same firm for no goal to be scored in the opening 30 minutes is outstanding value and should be backed accordingly.
For those seeking bigger returns from their investments on this game, De Boer's men look capable of edging a nervy encounter against the poor travelling Scots and those seeking to back bigger prices should snap up the 6/1 (7.0) quote from Betway for Ajax to claim a 1-0 win on Wednesday.
|BEST BET||VALUE BET|
|First goal after 30 minutes at 21/20 (2.05) 2pts with Betway
||Ajax to win 1-0 at 6/1 (7.0) 1pt with Betway
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Willie Duncan is a freelance sports journalist. Willie, from Edinburgh, has covered Scottish football for over 10 years and he specialises in football betting markets from across Europe. You can also follow Willie on Twitter
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