The Black Stars won all three of their group-stage qualifiers on home soil by an aggregate scoreline of 13-1 and are favourites at 19/20 (1.95) with Betway to earn a crucial first-leg lead in Kumasi.
However, Bob Bradley's team did not drop a single point on the way to finishing top of their group and are available at 3/1 (4.00) to maintain their 100 per cent record with victory here.
Neither side have drawn a match so far this qualification campaign but you can get odds of 11/5 (3.20) on them bringing that run to an end with a stalemate in this one.
Bradley does not have fond memories of facing this opposition, having seen his USA side knocked out of the last World Cup at their hands in an extra-time defeat, while January's 3-0 friendly loss still looms fresh in the mind.
Nevertheless, the American insists that he will be going all out for victory in his bogey side's back yard and this confidence is undoubtedly fuelled by the form of key attackers Mohamed Salah and Mohamed Aboutrika.
With 11 goals between them, the pair are the first and second leading scorers in African qualifying and represent the main reason why the Pharaohs have not failed to score in 11 games since that friendly against these opponents.
They will be particularly confident of breaching a Ghanaian defence missing key men John Boye, John Mensah and Issac Vorsah, while their hosts' high back line should make them especially vulnerable to Egypt's trademark counterattacks.
Considering that James Kwesi Appiah's men have only failed to score once in their last 19 matches, a high-scoring encounter seems likely, and odds of 13/10 (2.30) are not to be missed on over 2.5 goals going in.
That bet would have paid out in two of the last three meetings between the sides, as well as eight of their 12 combined qualifiers so far.
|Over 2.5 goals for a 1pt stake at 13/10 (2.30) with Betway
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Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.