Expectations are sky-high in a football-mad country which has been deprived of seeing its team at a World Cup for 15 years, yet the visit of Chile could put the celebrations on hold.
Jorge Sampaoli's side have won their last four qualifiers, very nearly beat World Champions Spain three weeks ago and generally produce a fast flowing brand of entertaining football.
This could be a superb contest with Colombia priced by BetVictor at evens (2.00) with Chile offered at the eye catching price of 31/10 (4.10).
That Chile provide such great entertainment is down not only to the fact that they play exciting football, but also to their somewhat lax defending.
They score goals but they also concede, while Colombia regularly find the back of the net, scoring in each of their last 11 home qualifiers.
Chile for their part have netted in each of their last seven matches in all competitions (including against Brazil and Spain).
Therefore backing both teams to score at 9/10 (1.90) looks to be the logical conclusion and is a bet that has paid out in six of Chile's last eight qualifiers.
|Both teams to score at 9/10 (1.90) 1.5pts with BetVictor
Sign up with BetVictor for a free £25 bet and back Phil's selection for this game
Phil Kitromilides is a sports journalist and TV Presenter in Madrid