The visitors have got a fantastic record against City, winning six of the last eight meetings, including taking four points from the Premier League runners up last season.
Everton will come into this match full of confidence with an unbeaten league record to defend.
Roberto Martinez's side beat Newcastle 3-2 on Monday night to take them to fourth position in the Premier League, three points behind Arsenal who occupy top spot.
The Toffees have won their last three league games in a row, with their only defeat this season coming in the Capital One Cup against Fulham last week. Bet365 price them at 4/1 (5.00) to continue their fine form.
Manchester City were passengers midweek against a rampant Bayern Munich side, who came out on top 3-1 in the Champions League, a scoreline that flattered City.
This match followed their surprise defeat away at Aston Villa in the league last Saturday, with defensive lapses costing them the points at Villa Park.
Pellegrini will be looking for a reaction on Saturday lunch time, and Bet365 price them as favourites for the clash at 13/20 (1.65) to take all three points. The same firm price the draw at 14/5 (3.80).
A bet that stands out in this fixture is over 2.5 goals at 7/10 (1.70) with Bet365. It may be a touch short, but when you consider the bet would have paid out in City's last five fixtures, which have included a 3-2, 4-1 and 5-0, its certainly worth investing in. Over 2.5 goals has also landed in Everton's last three matches.
For those looking for more value, Everton's main man Romelu Lukaku is a fantastic 9/4 (3.25) to net in 90 minutes on Saturday.
The Belgium international has been a huge hit since arriving from Stamford Bridge on loan, netting three goals in his last three matches, including the winner against West Ham away and a double at home to Newcastle.
|Over 2.5 goals for a 1.5pt stake at 7/10 (1.70) with bet365
||Romelu Lukaku to score anytime for a 1pt stake at 9/4 (3.25) with bet365
Sign up with bet365 for up to £200 in free bets