Alejandro Sabella's men are unbeaten in 11 qualifying fixtures and are 3/4 (1.75) favourites with BetVictor to come out on top against a side whom they beat 3-1 in Cordoba one year ago.
La Albiroja are almost in need of a miracle to have any hope of making it to Brazil but are available at 4/1 (5.00) to secure their third consecutive home win over their more illustrious opponents in Asuncion.
The visitors have drawn their last three qualifiers in a row and you can get odds of 14/5 (3.80) on them making it four with a stalemate at the Estadio Defensores del Chaco.
The hosts have struggled to maintain the extremely high standards set under former boss Gerardo Martino, who led them to two successive World Cups and a silver medal at the 2011 Copa America, sacking two managers since the current Barcelona boss's departure two years ago.
However, the recently appointed Victor Genes has offered hope in his first two games in charge that pride may soon be restored to Paraguayan football following a miserable qualification campaign, having held Germany to a 3-3 friendly draw in Kaiserslautern before routing Bolivia 4-0 on Friday.
Those seven goals in two games will have given the hosts more confidence than they have enjoyed in a long time and, with little to lose, they will surely go all out for an even bigger morale boost against La Albiceleste.
Considering that Argentina have failed to keep a single clean sheet on the road in qualifying, odds of 5/6 (1.83) look extremely inviting on both sides finding the net, particularly with the visitors' first-choice defensive partnership of Federico Fernandez and Ezequiel Garay suspended, along with midfield lynchpin Javier Mascherano.
That bet would have paid out in three of the last four clashes between the sides, as well as the guests' last five competitive away games.
|Both teams to score for a 2pt stake at 5/6 (1.83) with BetVictor
Sign up with Bet Victor for a free £25 bet and back Al's selections for this match
Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.