The 2008 winners recorded a 2-1 away victory when these sides met in the Capital One Cup in August and are 8/13 (1.57) favourites with Coral to come out on top in front of their own fans on Tuesday evening.
Aidy Boothroyd's men have endured a difficult start to the season, with five of their six games resulting in defeats, and they are on offer at a lengthy 7/2 (4.50) to emerge victorious in this match.
The hosts have drawn two of their last four games and you can get odds of 5/2 (3.50) on this tie going into extra-time after a draw in 90 minutes.
The Cobblers were left fuming after their league defeat at Bristol Rovers on Saturday, when they felt they were denied several legitimate penalty appeals before seeing striker Roy O'Donovan sent off for two yellow cards.
Their frustration was no doubt piqued after failing yet again to score their first away goal this season, as last year's Achilles heel shows no sign of healing.
Boothroyd's side have now failed to hit the back of the net in nine of their last 15 competitive matches on the road and will find it all the more difficult to end that run without the suspended O'Donovan and with Clive Platt still finding his feet after injury.
These sides have met five times since the Dons moved to Milton Keynes and Karl Robinson's men have won four of those, so they will be particularly confident of progressing to the next round considering their guests' toothless form.
Although renowned for their attractive passing game, the hosts demonstrated an impressive resilient streak in Saturday’s 1-0 away win over Sheffield United and odds of 2/1 (3.00) are well worth backing on them coming out on top without conceding a goal.
|MK Dons to win to nil for a 1pt stake at 2/1 (3.00) with Coral
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Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.