Indeed the Stade Gerland is a particularly well-known setting for the Spanish giants, having played there three times in the last three years during the Champions League.
As expected, Carlo Ancelotti's men swatted away Bournemouth with the minimum of fuss recording a 6-0 victory on Sunday and Bet365 price them at 4/6 (1.66) to claim their second pre-season win.
Lyon, meanwhile, who finished third in Ligue 1 last season under the auspices of former Arsenal player Remy Garde, can be backed at 7/2 (4.50).
Yet this is a game Madrid in which will be confident of getting a comfortable victory and backing them to lead at half-time, offered at 6/5 (2.20), looks to be an excellent bet.
Los Blancos' squad is looking imperious with the summer additions of Asier Illarramendi, Isco and Dani Carvajal, with the latter two particularly impressive against Bournemouth.
Lyon's squad has hardly been reinforced and, with Cristiano Ronaldo looking in arguably the shape of his life, Madrid should be backed confidently to be ahead at half-time.
|Real Madrid to lead at half time at 6/5 (2.20) with Bet365|
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Phil Kitromilides is a sports journalist and TV Presenter in Madrid