That defeat was the Italians' first in 13 games in this season's competition and they are available at 10/11 (1.91) with Bet Victor to return to winning ways this evening.
However, Aykut Kocaman's visitors have an impressive away record of four wins and one draw in Europe this campaign so may fancy their chances of securing another victory in this match at odds of 17/5 (4.40).
The home fans have only witnessed three draws in 25 games in all competitions but you can get odds of 13/5 (3.60) on this one finishing all square behind closed doors.
Ogenyi Onazi's sending off at the Sukru Saracoglu Stadium could well prove to be the decisive moment of the tie, as it tipped the balance of a tight first leg in the Turks' favour, allowing them to pick up a lead that they are unlikely to relinquish in a hurry.
The visitors have become masters of the resolute away performance in this competition, earning three 1-0 wins and a 0-0 draw on their most recent travels and will be confident of putting in a repeat performance to kill the tie off.
Having kept seven clean sheets in their last nine Europa League clashes, Fenerbahce are more than capable of keeping things tight in this game and odds of 4/5 (1.80) look too good to miss on them restricting the scoreline to under 2.5 goals.
Salih Ucan was a second-half substitute in the first leg but, after grabbing both goals in Sunday's 2-0 league win over Orduspor, the 19-year-old midfielder is in line to play from the start in Rome.
The exciting youngster is attracting attention for his prolific return of four goals in his last five games having opened his account for the club in the 1-1 draw with Viktoria Plzen in this competition, and offers exceptional value at 9/1 (10.00) to hit the back of the net tonight.
|Under 2.5 goals at 4/5 (1.80) with Bet Victor
||Salih Ucan to score anytime at 9/1 (10.00) with Bet Victor
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Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.