Many will have United as favourites to progress now and they are a 10/1 (11.0) shot with Paddy Power to taste glory at Wembley in May.
Shakhtar Donetsk and Borussia Dortmund played out a 2-2 draw, so it is all to play for in the return leg in Germany. Juventus and Paris Saint-Germain secured away victories and they are very much in the driving seat to progress to the last eight.
Paddy Power have already paid out on Manchester United lifting the Premier League title this season after they built up a commanding 12-point lead, which won't be pegged back in my opinion. With Spain and Germany also seemingly decided in terms of the title race, it is up to us speculators to look for different angles and trends to profit in the market.
If we look towards the bottom in each league, you will find teams that will start to over perform as they battle for survival.
Looking ahead to the weekend, Mainz are a match for most teams at home and they can beat Schalke at 11/8 (2.38) with Paddy Power who may have their minds on the Champions League in midweek.
Liverpool have had a busy week in Europa League action so they are worth laying at home to Swansea. Michael Laudrup's men can can be backed on the double chance market at 7/5 (2.40) with Paddy Power.
|Mainz to win at 11/8 (2.38) with Paddy Power||Swansea or Draw (Double Chance) at 7/5 (2.40) with Paddy Power|
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