The team from Pamplona meanwhile are rock bottom of the La Liga table and surely will be more focused on survival than turning around a two goal deficit.
It is likely then that we will see both managers make plenty of changes to their starting elevens with William Hill pricing a home win at 1/2 (1.50) while Osasuna can be backed at 6/1 (7.00) and the draw offered at 3/1 (4.00).
Yet given the slightly sterile nature of the second leg, and the fact that the match is not of pressing importance to either side, backing under 2.5 goals at 10/11 (1.91) looks to be a great option.
This was the tip for the first leg and it comfortably paid out, while this has also proved to be the correct selection in eight of the last nine competitive matches that Osasuna have played.
For a value bet try backing a goal less first half at 21/10 (3.10) with this bet paying put in seven of Osasuna's last night fixtures in all competitions.
This bet also paid in the two previous meetings between the sides this season, which Valencia won 1-0 and 2-0 respectively, all the goals coming in the second half.
|Under 2.5 goals at 10/11 (1.91) with William Hill
||Under 0.5 goals first half at 21/10 (3.10) with William Hill|
Sign up with William Hill for a free £25 bet and back Phil's selections for this match
Phil Kitromilides is a sports broadcaster working on radio and TV in London and Madrid. You can also follow Phil on Twitter.