Over 2.5 goals has paid out in each of the last seven meetings, while both teams to score has proved to be a correct selection in the last eight encounters.
For those looking for solid, but short-priced selections, this is where the big money will go once again, with over 2.5 goals offered at 11/25 (1.44) by William Hill and both teams to score available at 2/5 (1.40).
The odds are of course short, but only because both of these bets are extremely likely to pay out. However, the majority of people will be looking for a bit more value, and the price of 5/4 (2.25) on over 3.5 goals looks tempting.
This bet has paid out in five of the last seven Clasicos, and with Real Madrid trailing 3-2 on aggregate they
know they must score.
This should lead to an open game, meaning plenty of goals and backing at least four to be scored makes sense.
There are no prizes for guessing which two players lead the goalscorer markets. Lionel Messi scored a penalty in the first leg as well as two vital goals against Osasuna in La Liga on Sunday, he is a 4/1 (5.0) shot with William Hill to break the deadlock.
Cristiano Ronaldo opened the scoring in last week's encounter and he too, is a 4/1 (5.0) play to score first. Those wanting to back either player to find the net anytime can do so at 4/5 (1.80) with William Hill.
In the outright market, Madrid are priced at 3/2 (2.50) while Barca can be backed at 13/10 (2.30) and the draw is offered at 5/2 (3.50).
Backing a draw between the two sides could be a worthy of a small value bet, with last year's Spanish Super Cup game at the Bernabeu finishing 2-2, a repeat of which would also see a pay out on our initial selection of over 3.5 goals.
|Over 3.5 goals at 5/4 (2.25) with William Hill
||The Draw at 5/2 (3.50) with William Hill|
Sign up with William Hill for a £25 free bet and back Phil's selections for this game
Phil Kitromilides is a sports broadcaster working on radio and TV in London and Madrid. You can also follow Phil on Twitter.