Del Bosque's side are the clear favourites ahead of this one, and we present five odds that could help you secure a profit from tonight's action
We're back to Group C this evening as Italy face Croatia, with Spain taking on Ireland in the late kick-off.
The Spanish were held to a 1-1 draw in their opening clash with Italy, while Ireland's 3-1 defeat sees Ireland sit rock bottom of the group going into this clash.
||Ireland to beat Spain
|Republic of Ireland are the longest pre-match odds of the tournament so far to win against Spain.
||Fabregas to score first
|Vicente Del Bosque chose to start without a recognised striker against Italy, the Spain boss went with Barcelona's Cesc Fabregas to lead the line.
||St Ledger to score anytime against Spain
|Sean St Ledger scored Republic of Ireland's only goal of the campaign. Can the Leicester City defender do it again?
||Spain to beat Ireland 3-1
|Ireland lost their opening group match 3-1 to Croatia.
||Iniesta to score and Spain to win
|He scored the winning goal in the final of World Cup 2010, and the Barcelona man is included in William Hill's special for tonight's match.