We weigh up the probable line-ups for crunch clash at Eastlands...
It is a huge game, with the likelihood being that whoever wins will take fourth spot and a place in the qualifying rounds of the Champions League next season.
A win for Spurs would definitely secure it, a win for City and they would need only to match Tottenham's result on the final day of the season - when Harry Redknapp's men travel to relegated Burnley, while Roberto Mancini's side face West Ham United at Upton Park.
With so much at stake, Goal.com UK took a look at the Castrol Rankings to compare the likely starting XIs for each club - and it produced some fascinating results.
Spurs are the favoured side, winning seven of the 11 head-to-heads, and they also hold a significant points advantage. That is aided largely by Shay Given's absence through injury - the Manchester City goalkeeper's deputy, Marton Fulop, ranks a massive 1018 places lower on the Castrol Rankings.
Also crucial will be Redknapp's team selection. Heurelho Gomes is a doubt with a groin injury, and with Carlo Cudicini a long-term absentee, it would fall to Ben Alnwick to take Spurs' goalkeeping jersey. Alnwick does not rank at all on the Castrol list, having not played a top-flight game in the past 12 months.
Another key decision will be whether to play Ledley King, whose knee trouble usually prevents him from playing two games in a week. Having already featured against Bolton on Saturday, King could make way for Sebastian Bassong - who is actually ranked higher than the Tottenham captain.
The Castrol Rankings produced the following results:
|Spurs by 290pts
|Spurs by 44pts
|Spurs by 192pts
|Man City by 18pts||Ledley
|Man City by 36pts||Gareth
|Spurs by 408pts
|Spurs by 103pts
|Man City by 10pts
|Man City by 546pts||Roman
|Spurs by 30pts||Jermain
Overall head-to-head score:
Manchester City 4 Tottenham 7
Overall points advantage: Tottenham by 462
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