The 61-year-old manager has recalled the Barcelona striker upon his return to fitness, with Roberto Soldado and Chelsea striker Fernando Torres his other striking options.
However there is no place for Torres's club team-mate Juan Mata. Other notable absentees includes Bayern Munich's Javi Martinez, strikers Alvaro Negredo and Fernando Llorente, all of whom miss out.
Speaking about Villa's inclusion at a press conference Del Bosque said: "It is unusual that Villa is coming. He has hardly played but we thought it would give him a lift.
"All the information we have is that he is well. He is our leading goal scorer and more than that, we felt it right that he came whether he plays or not."
However, Villa's club team-mate Carles Puyol is not included as the defender continues his recovery from a fractured cheekbone.
Spain play Saudi Arabia in a friendly match four days prior to opening their World Cup qualifying campaign against Georgia on September 10.
|Iker Casillas||Real Madrid|
|Jose Manuel Reina||Liverpool|
|Raul Albiol||Real Madrid|
|Sergio Ramos||Real Madrid|
|Alvaro Arbeloa||Real Madrid|
|Xabi Alonso||Real Madrid|
|Benat Etxebarria||Real Betis|
|David Silva||Manchester City|