Jose Mourinho has already booked his second clash with Pep Guardiola in as many months, as the Manchester derby plus Liverpool's clash with Tottenham loom
Manchester United have been drawn to take on Manchester City at Old Trafford in the fourth round of the EFL Cup on October 24.
It will be the second meeting between Jose Mourinho and Pep Guardiola in as many months, with the latter edging the first clash when City beat United 2-1 at Old Trafford in September.
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Both Manchester sides won on the road on Wednesday, City seeing off Swansea 2-1 at Liberty Stadium while Marcus Rashford inspired a 3-1 Red Devils' win at Northampton Town.
The City-United showdown is one of four all-Premier League ties that include a London derby between West Ham and Chelsea at London Stadium.
Antonio Conte's men enjoyed a spectacular 4-2 win at Leicester City in the third round, while in contrast, the Hammers limped past League Two Accrington Stanley courtesy of a stoppage-time free-kick from Dimitri Payet.
Elsewhere, Tottenham will visit eight-time winners Liverpool – both the Reds and Spurs ran rampant in their EFL Cup openers against Derby and Gillingham this week.
Mauricio Pochettino's men looking particularly impressive in a 5-0 result at White Hart Lane.
Arsenal take on Reading at the Emirates Stadium, four years on from their quarter-final thriller in which the Gunners came back from 4-0 down to win 7-5.
Southampton will take on Sunderland afterClaude Puel's side followed up their first league victory of the season last weekend by beating Crystal Palace 2-0.
Meanwhile, two goals from defender Paddy McNair helped Sunderland fight back to beat Queens Park Rangers 2-1.