Canaries boss Chris Hughton makes a staggering 10 changes for the visit of Spurs with Steven Whittaker set to make his debut, while Villas-Boas gives the France captain a start
The former Newcastle boss has also handed a debut to Steven Whittaker, after he suffered an ankle injury while playing for Rangers against Celtic which has kept him out of action for the Norfolk club so far.
Michael Turner, who headed the Canarie's equaliser against Paul Lambert's new side is the only survivor from Villa Park.
Andre Villas Boas, meanwhile, has chosen to name French goalkeeper Hugo Lloris between the sticks, after Brad Friedel returned during the 2-1 win against Southampton at St. Mary's on Sunday.
William Gallas and Jan Vertonghen make way for Michael Dawson and Kyle Naughton respectively, while youngsters Tom Carroll and Iago Falque also start at Carrow Road.
Norwich starting XI: Bunn; Whittaker, Turner, Bennett, Tierney; Snodgrass, Fox, Butterfield, Surman; Howson, Morison
Subs: Rudd, Holt, Jackson, E. Bennett, Garrido, Barnet, Tettey
Tottenham starting XI: Lloris; Walker, Dawson, Caulker, Naughton; Livermore, Carroll; Falque, Sigurdsson, Bale; Dempsey
Subs: Cudicini, Vertonghen, Huddlestone, Lennon, Defoe, Townsend, Smith