Brentford did brilliantly to cause an upset and dump Everton out of the competition in the last round, but now have a tough midweek trip to St Andrew’s.
The home side are generally strong at home and put up a strong resistance against the cream of the crop in the Premier League, so a struggling League One side should not be much of a problem.
But all is not lost, as manager Alex McLeish has confirmed that he will ring in the changes to his line-up, as the club has a Birmingham derby with Aston Villa that looms large.
The Bees will want to beat the odds again and manage to scrape a positive result against a second-string Birmingham side.
Leicester City vs West Bromwich Albion
Leicester boss Sven-Goran Eriksson’s primary focus is on getting his side higher up in the Championship standings, following a miserable start to the season. But getting to the quarter-finals of the competition could be inspirational for his charges, as the club has not reached that stage in the last 10 years.
But on the flipside, the Swede has not had enough time to gauge the true strength of his squad, and may look towards fielding a second-string line-up to see how some of his fringe players perform against Premier League opposition.
Meanwhile, the Baggies disposed of Manchester City in the last round, and have been in fine form of late. They have managed to beat Arsenal, Fulham and draw with Manchester United in the league.
But manager Roberto Di Matteo will not have Peter Odemwingie available, as the club’s top scorer is out with a knee injury. In his absence, Roman Bednar and Simon Cox are expected to lead the line.
Wigan Athletic vs Swansea City
Wigan boss Roberto Martinez is in for an emotional ride as he tries to mastermind a victory over a club that he played for and managed.
The Spaniard played for Swansea between 2003 and 2006, before returning to manage them a year later. But his relationship with the fans has been somewhat strained, owing to his departure to join Wigan in 2009.
But to the credit of the Welsh club, they have managed to continue well in his absence, as they almost achieved promotion to the Premier League last term - and look set to better that if their current form continues.
But the travellers are traditionally not a very successful side in the League Cup. Still, they will fancy their chances against the Latics, who have been eliminated from this competition thrice in the last four years by lower league clubs.