The 54-year-manager intends to rest his first-teamers, with the club slipping into the relegation places in the Premier League, but is confident of upsetting the form book
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But, with the Norfolk outfit toiling in the relegation places, Hughton will opt against risking his first-choice XI, though remains adamant his side can cause an upset against David Moyes' men.
"It's a game we're very much looking forward to, and one of course we're looking to win," he told reporters.
"I'll be using the squad tomorrow night, but I'll be putting a team out that I think will be good enough to win a tough game.
"You always look for the positives, and one positive is that we did beat Manchester United last season [1-0 at Carrow Road in November 2012]."
United made it to the fourth round of last year's tournament, while Norwich were eliminated by Aston Villa in the quarter-finals.