The 48 entrants are split into four seeding pots based on their club coefficients, with each of the 12 groups to contain one team from each tier.
No club can meet a side from their own association.
Apart from the aforementioned favourites, Celtic and Legia Warsaw will also be intrugued to find out their opponents for the group stages and both rivals could be paired with one another once more after previously locking horns in the Champions League qualifiers in what could be a mouthwatering encounter.
The Polish outfit recorded a 6-1 aggregate win over Celtic yet were eventually eliminated after Uefa slapped them with a 3-0 loss by default in the second leg of the tie for fielding an ineligible player.
Other high-profile teams in the draw include PSV, Feyenoord, Wolfsburg, Borussia Monchenglabach, Everton, Torino, Saint-Etienne and Dinamo Moscow.
POT 1: Sevilla (ESP), Inter (ITA), Tottenham (ENG), PSV (NED), Napoli (ITA), Dynamo Kyiv (UKR), Villarreal (ESP), Fiorentina (ITA), Salzburg (AUT), Metalist Kharkiv (UKR), Lille (FRA), Copenhagen (DEN)
POT 2: Steaua Bucharest (ROU), Standard Liege (BEL), PAOK (GRE), Celtic (SCO), Besiktas (TUR), Wolfsburg (GER), Club Brugge (BEL), Dnipro (UKR), Trabzonspor (TUR), Panathinaikos (GRE), Sparta Prague (CZE), Borussia Monchengladbach (GER)
POT 3: Everton (ENG), Young Boys (SUI), Dinamo Zagreb (CRO), Zurich (SUI), Estoril (POR), Legia Warsaw (POL), Partizan (SRB), Torino (ITA), Feyenoord (NED), Saint-Etienne (FRA), Guingamp (FRA), Rio Ave (POR)
POT 4: Dinamo Moscow (RUS), Krasnodar (RUS), Rijeka (CRO), Lokeren (BEL), Asteras Tripolis (GRE), Slovan Bratislava (SVK), Apollon Limassol (CYP), Qarabag (AZE), Helsinki (FIN), Astra Giurgiu (ROU), Dinamo Minsk (BLR), Aalborg (DEN)