Despite resting several players including Kyle Walker, Andros Townsend and Paulinho bet365 still make the visitors overwhelming favourites at 1/3 (1.33) to clinch a win which could see them qualify for the knockout stages if Anzhi Makhachkala and Tromso's match finishes all square.
Sheriff's two Europa League group games have both ended as draws and a third successive stalemate is available at 17/4 (4.20) with bet365.
The home side are 11/1 (12.0) with the same firm to pull off an unlikely victory although they currently sit top of their domestic league with 29 points from just 12 games.
Although Spurs should be able to get the victory they need, and Andre Villas-Boas is likely to field a team capable of beating the home side, it's a trend in the goals market which could be the best way to go in this game.
When you look back at this competition including qualification, three of Sheriff's four Europa League games season have seen under 2.5 goals and Spurs have shown their ability to secure low-scoring victories on the road on several occasions.
The London side have won four consecutive matches on their travels in all competitions but only one of those games saw over 2.5 goals and their staunch defence, which will be looking for a fifth away clean sheet in a row on Thursday night, could lead to another low-scoring encounter in Moldova.
With Spurs much too short to back at 1/3 (1.33) it's the 11/10 (2.10) on offer from bet365 looks a more attractive option.
|Under 2.5 goals at 11/10 (2.10) for a 1pt stake with bet365|
Sign up with with bet365 for up to £200 in free bets