The Dane concedes a lack of knowledge will put his Swansea side at a disadvantage, while Petrolul will be much more aware of their task coming into the fixture.
"When you play in the Premier [League] we all know each other. But I don’t think any of my players will have heard of them – not any one of their team," said Laudrup.
"We all know who Robin van Persie, Aaron Lennon and Mousa Dembele are. But no-one knows Gheorghe Grozav, [Hamza] Younes or the other guys.
"It's not being disrespectful, but the less you know an opponent, the more work you have to do."
Laudrup also warned his players not to treat the Liga I side lightly.
"Eight years ago who knew of teams like Shakhtar Donetsk and then suddenly they are a huge team," said the former Barcelona, Real Madrid and Ajax midfielder.
"Who knew Cluj? They were in the group stages of the Champions League and close to the knockout stages.
"That’s the way it is with teams from the east. I don’t want to become victim of a team that was not so well known."