An injury dilemma at left-back has led to the inclusion of both the versatile Portuguese defender and the 18-year-old debutant, while a number of key players are rested
Injuries to Ashley Cole and Ryan Bertrand mean that Paulo Ferreira fills in at left-back, with 18-year-old Dutchman Nathan Ake making his first start for the club in front of the veteran Portuguese defender.
Juan Mata, Oscar and Eden Hazard all drop to the bench, having played a big part in the Blues' hectic recent schedule of four games in eight days, while Fernando Torres will be hoping to recapture his fine form from the first leg as he replaces the cup-tied Demba Ba.
John Terry returns to the starting line-up in the place of Branislav Ivanovic in order to make his 100th European appearance for the club, while Frank Lampard, Yossi Benayoun and Victor Moses also come into the side.
Chelsea starting XI: Cech; Azpilicueta, Luiz, Terry, Ferreira; Ake, Lampard; Ramires, Benayoun, Moses; Torres
Subs: Turnbull, Ivanovic, Oscar, Mikel, Hazard, Marin, Mata
Rubin Kazan starting XI: Ryzhikov, Kuzmin, Ansaldi, Navas, Marcano, Orbaiz, Kasaev, Eremenko, Karadeniz, Natcho, Rondón.
Subs: Arlauskis, Kaleshin, Sharonov, Ryazantsev, Kislyak, Gokhan Tore, Dyadyun