Another Clasico could be in the offing as Manchester United's conquerors, Real Madrid, could face bitter rivals Barcelona after the Blaugrana became the first team to overturn a 2-0 first-leg deficit in the competition's history against AC Milan.
Joining the two Spanish giants are Bayern Munich, who limped through against Arsenal after an impressive first leg. The German powerhouse are one of the favourites for the competition and could set-up an all Bundesliga clash with Borussia Dortmund, who overcame Shakhtar to reach this stage.
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English sides have fared better in the Europa League, however, and after a dramatic Thursday night of action there will be three Premier League clubs in the hat on Friday morning.
Papiss Cisse was the hero for Newcastle as they went through 1-0 on aggregate against Anzhi, Chelsea came back from a first-leg deficit to dispatch Steaua Bucharest at Stamford Bridge and Tottenham dramatically went through at San Siro after an extra-time strike from Emmanuel Adebayor saw off Inter on away goals.
With the threat of Benfica, Lazio and Fenerbache left for the English trio, it promises to be an intriguing draw. Rubin Kazan and Basel complete the last eight.
You can follow build-up, latest news and reaction from both the Champions League and Europa League draws LIVE with Goal.com from 10.30GMT.