Benitez's side trail Romanian club Steaua Bucharest 1-0 heading into the second leg at Stamford Bridge and, if they can overturn the deficit, the Blues will play four times in just nine days.
Chelsea also face a replay in the FA Cup sixth-round tie with Mmanchester United that has been scheduled for April 1, three days before the first leg of any Europa League last-eight tie.
"Maybe somebody else will blame me. They will say it's my fault - because everything is my fault," Benitez quipped to reporters.
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"When you have to play every three days, or two days, which is the situation, you have to look at your squad, your players and the positions they play.
"Centre-backs and goalkeepers can play more games, but for wingers, full-backs, strikers, it is more difficult because of the intensity of the runs and the distance they run.
"You have to see which ones recover quickly and are fit. Others are older and need more time. So you have to analyse everything and decide - and still you get criticised.
"If you lose it's, 'You picked the wrong player.' It's quite difficult."