Brendan Rodgers makes just three changes from the Reds' weekend victory over Reading, with youngsters Raheem Sterling and Suso, along with Joe Allen, making way
Pepe Reina is still out of action due to a hamstring injury, so Brad Jones continues in the Spaniard's place.
Youngsters Raheem Sterling and Suso drop out of the side that faced Reading at the weekend, being replaced by Oussama Assaidi and Stewart Downing.
The third change to Brendan Rodgers' side sees Jonjo Shelvey, who has scored three goals in this season's competition, replacing Joe Allen.
The visitors include Samuel Eto'o and former Blackburn man Chris Samba in their starting line-up but ex-Arsenal and Chelsea midfielder Lassana Diarra misses out with a knee injury.
Liverpool: Jones; Wisdom, Skrtel, Agger, Johnson; Gerrard, Sahin, Shelvey; Assaidi, Suarez, Downing.
Subs: Gulacsi, Henderson, Carragher, Allen, Sterling, Suso, Yesil.
Anzhi Makhachkala: Gabulov; Zhirkov, Joao Carlos, Samba, Agalarov; Boussoufa, Gabulov, Shatov; Smolov, Eto'o, Carcela-Gonzalez.
Subs: Pomazan, Gadzhibekov, Lahiyalov, Tagirbekov, Logashov, Muhammad, Traore.