The winger has netted 16 league goals and made 13 assists this term and, even with Robert Lewandowski moving to Bayern Munich in the summer, his coach backs him to lead the way
The Poland international finished the season as the Bundesliga's top scorer with 20 goals and will leave the North Rhine-Westphalia club to join their rivals and league champions Bayern Munich.
However, Klopp is unworried about the loss of the 25-year-old striker, insisting that Reus, who scored 16 league goals and set up a further 13 from the wings in 2013-14, can take over the responsibility as the side's main scorer.
"Next season it's Marco Reus's turn to finish as Bundesliga top scorer," the coach told reporters after the 4-0 win over Hertha on Saturday.
Lewandowski netted twice in his final league game in a Dortmund shirt, scoring a neat free kick to wave goodbye to the BVB faithful, and Klopp joked that it was one of the very few dead balls that he has seen him score.
"He practiced free kicks for four years," the coach added. "From doing 8000 in training, no more than three went in - unfortunately this is the truth."
The 46-year-old then spoke of his happiness after ending the season with a win.
"I am extremely satisfied," he enthused. "We have deserved it and pretty much won because we were highly motivated to get to 71 points."