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But Jones is confident the squad can overturn a two-goal deficit, pointing to his team-mates' mental strength and is now only interested in looking forward rather than dwelling on past failures.
"We don't give up, you know," he told Uefa.com. "Our mentality is to keep training hard, keep doing the right things and eventually it will turn.
"We truly believe that, and that’s what will happen. We've got to be patient and stick at it but it will come. We didn't play as well as we'd like to have played [in Greece] but there's no point dwelling on it now.
"We've got to deal with what's happened and look forward to the future, and the future is putting in a performance at Old Trafford that will lift the crowd, lift the players and turn it around. Only we can do that."
Chris Smalling and Jonny Evans will miss Wednesday's second leg through injury, but Jones hopes himself Smalling aid United's cause when the fellow England international returns to full fitness.
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"I thought every time we played together, we understood each other's game and we complemented each other well. Hopefully that can kick off at Manchester United as well."