The Rossoneri boss remains confident of reaching the quarter-finals of the Champions League despite losing the first leg 1-0 to Spanish title-chasers Atletico Madrid
Seedorf's men face an uphill battle if they are to do so on Tuesday after suffering a 1-0 defeat in the first leg of their last-16 tie against Atletico Madrid at San Siro in February.
Milan occupy a mid-table position in Serie A and will be underdogs against an Atletico side who sit second in La Liga but the Dutchman remains confident of an upset.
"I've often been in situations in which we're not the favourites, even in years in which we achieved important things," he told the press.
"The favourites were and are Atletico Madrid. I think the two sides will play in a similar manner to the first leg.
"They have a narrow advantage - the game is open and I'm expecting changes with regards to the first leg.
"We have to fight as a team and play with our hearts. These things come before the technical and tactical aspects.
"Our approach will be similar to the one in the first leg. We will be aggressive and try to score.
"Milan have a great history and we have to honour the club and the shirt.
"The players are also extremely motivated. It's an important moment for everyone - we know we can write a beautiful page in this club's history."