The Manchester City striker will miss the Champions League last 16 first leg tie after being substituted in the victory over Tottenham and will be unavailable for a month
The Argentina striker, who has scored six goals in his last five games since returning from a calf injury he picked up in December’s win over Arsenal, tweaked his hamstring shortly after opening the scoring in Wednesday’s 5-1 thrashing of Tottenham at White Hart Lane.
City, who returned to the top of the Premier League in midweek, are due to face Tata Martino’s side in the first leg of their Champions League last 16 tie at the Etihad Stadium on 18 February, with the return fixture at Camp Nou scheduled for 12 March.
Manchester City manager Manuel Pellegrini said: "[Samir] Nasri continues treatment. Javi Garcia and Kun Aguero are injured. [The] doctor has seen Aguero and he will be out for a month."
"It will be difficult because he is a top player for us but we have the players to replace him.
"He has just come back from injury and Alvaro Negredo, Stevan Jovetic and Edin Dzeko can replace him."