The Frenchman spent the early part of the summer attempting to secure the services of Higuain, who has scored 10 goals in 18 appearances for new club Napoli, but, after failing to meet Real Madrid's valuation of the Argentina international, eventually sanctioned the club-record signing of Ozil.
The former Real Madrid team-mates face-off on Wednesday in Italy, looking to secure Champions League qualification - potentially at the expense of the other - but, whatever the outcome, Wenger is adamant that he has no regrets over missing out on Higuain.
|11/4||Mesut Ozil is 11/4 with Coral to score anytime in Napoli v Arsenal|
"There were a lot of statements that were not true about Higuain. He has joined [Rafa] Benitez. He is in good hands and shows he is a great striker [but] we have Olivier Giroud who shows as well that he is a great striker."
Despite recording four victories from their five games, Arsenal still have work to do in order to ensure qualification. The Premier League leaders need only to avoid defeat by a three-goal margin to progress and a point would ensure top spot in a group that also includes last year's runners-up, Borussia Dortmund.
Wenger added: "Our priorities are simple: First qualify, if possible top [of the group]. For me, the first priority is to qualify. If we finish top, it is even better.
"[The atmosphere] is part of the big games; we know how to deal with that. You have that everywhere. We played everywhere in Europe, we are used to this kind of atmosphere - when you go from Fenerbahce to Dortmund, you are used to this kind of atmosphere."