The German giants recorded a 2-1 victory over the Gunners at the Emirates Stadium when last they met thanks to Robert Lewandowski's late strike and the BVB boss is looking forward to a similarly tight encounter at Signal Iduna Park, calling upon his men to stifle the north Londoners.
"It will be an intensive match with many duels," he told reporters. "At this level, neither team can surprise the other.
"Small things make a difference, such as when [Santi] Cazorla hit the bar [at the Emirates]. If Arsenal are stronger at [our] home it is because we let them be."
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He added: "Had we won the last 70 home games, it would be as much history as Arsenal's current away run. We want to write our own story."
The Dortmund coach also hinted that Mats Hummels will not be involved on Wednesday but indicated that the outlook is more positive for left-back Marcel Schmelzer.
"At the moment, it seems that Mats will not play," he remarked. "With Marcel, it looks a lot better."
Attacker Marco Reus echoed his coach's sentiments that Arsenal will pose a tough threat but is confident that BVB can emerge victorious.
"It will be another 50-50 match," the Germany international opined. "I believe we showed a great performance in London and will have to do so again. We know the smallest mistake will be punished.
"We have improved since Napoli. You can't compare this to the league, this is the Champions League."