The 45-year-old coach is hoping to strike the right chord in Tuesday's Champions League semi-final second leg against Jose Mourinho's men to seal their final berth
The Bundesliga giants face the Blancos at the Bernabeu knowing their 4-1 aggregate lead makes them overwhelming favourites to progress to the final in May.
However, with Mourinho's men having an away goal, Klopp admits the outcome could depend on how he fares tactically.
"Real Madrid believe they can turn around the tie tomorrow and they will act accordingly. Their fans weren't happy with the first leg, and the team will have to set an example from the first second," the coach told reporters.
"We know about our qualities and we gave Madrid a lot of problems in the last three games against them. It won't be a solely defence-based game tomorrow, nor will it be an offence-focused one. Balance is key."
Despite preliminary reports suggesting Lukasz Piszczek could miss Tuesday's second leg through injury, the 45-year-old revealed the defender could still recover in time to face the Liga giants.
Klopp added: "I'm not sure if Lukasz will play, yesterday he did a little bit of running, but we will see tomorrow."
Tuesday's match at the Santiago Bernabeu is scheduled to kick off at 19.45BST