Qualification chances are finely balanced following the 1-1 first-leg draw in Spain, when Danny Welbeck opened the scoring only to be pegged back by Blancos icon Cristiano Ronaldo.
|MAN UTD v MADRID LATEST
|7/1||Manchester United v Real Madrid is 7/1 with BetVictor to finish 1-1
With suggestions that Ronaldo feels underappreciated in Madrid, Patrice Evra has outlined an intention to "kill him with love" while, as revealed by Goal.com, United put on a charm offensive to ensure that they are in pole position to re-sign him should he opt to depart La Liga.
It is also set to be a milestone game for Ryan Giggs. The veteran midfielder, fresh from signing a one-year contract extension, was rested for Saturday's win over Norwich City so that he can make his 1000th career appearance against the Spanish giants.
For his manager, Sir Alex Ferguson, the match is another opportunity to test his wits against Madrid coach Jose Mourinho. The two were rivals when the Portuguese was in charge of Chelsea but have enjoyed a friendly relationship ever since, their footballing battles stretching back to the Scot's defeat at the hands of Mourinho's Porto in February 2004.
United have had some bad memories at home to Madrid; winning 4-3 on the night in April 2003 but going out on aggregate thanks to the hat-trick heroics of the Brazilian Ronaldo, as well as a humbling defeat three years earlier when they fell three goals down on their own turf but could not recover past a 3-2 loss.