Jose Mourinho's men have been largely billed as favourites for the clash at the Santiago Bernabeu, but the Scot is confident that the Red Devils can grab a goal.
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"There can be late drama but we have to balance that with responsibility not to leave the door open."
The 71-year-old has overseen two Champions League triumphs with the Old Trafford outfit, and is of the belief that his current squad have the talent to help him earn a hat-trick of European titles.
When quizzed on the possibility of going all the way, he replied: "Our team? I think so, yeah. There's a great spirit about them."
Sir Alex also praised managerial counterpart Mourinho, predicting the Portuguese could go on to match his impressive trophy haul in the future.
He continued: "He is 50 years of age. He has 20 years to catch up on me and it is quite possible he could."