The Red Devils travel to Santiago Bernabeu on February 13 for the first leg of the two sides’ last-16 clash as the Portuguese and veteran managers meet for the 15th time.
Mourinho has bettered Sir Alex on seven occasions, losing just twice, but he has never won a Champions League tie at Old Trafford - and the Los Blancos boss is targeting a record 10th triumph in the tournament for the club after admitting retaining their La Liga crown is "impossible".
"The 10th Champions League is a target. But be aware that other teams may well win. We should work a lot for this, and especially this season because we are distanced in the league," Mourinho told RMC.
"Manchester United's clash is fantastic. I prefer that. Ferguson is a fantastic example. He comes to see my team and I do the same."
REPEAT OF A CLASSIC
Real Madrid and Manchester United are 50/1 with William Hill to draw 3-3 on February 13
However, the 49-year-old did admit that he was close to taking charge of England in 2008, but his commitment to Portugal saw him back away from the opportunity.
He continued: "One day, I want to return to England. I spent only three and a half years and I want to go back. But this is not a priority. Today, I just think about tomorrow's game and that's life for all coaches.
"I would like to coach the national team of Portugal and many people expect it there. I hope know this experience and play a World Cup or Euro.
"In 2008, I was ready to take the English team. But for me, it was Portugal that I want, even if you never say never. But England is my first love and it will remain so."