The out-of-form Spaniard is relegated to the bench while the Blues' creative trio is preserved in attack and Ashley Cole and Cesar Azpilicueta start as wing-backs
Eden Hazard will start as a false No.9 in the absence of the out-of-form Spaniard, with Juan Mata and Oscar tasked with providing the service for the tricky Belgian.
In defence, Roberto Di Matteo shifts to a back three of Branislav Ivanovic, David Luiz and Gary Cahill, with the returning Ashley Cole and Cesar Azpilicueta are expected to operate as wing-backs.
Juventus, meanwhile, prefer Fabio Quagliarella to Sebastian Giovinco up front in what is otherwise a full-strength lineup.
Juventus starting XI (3-5-2): Buffon; Chiellini, Barzagli, Bonucci; Lichtsteiner, Marchisio, Pirlo, Vidal, Asamoah; Vucinic, Quagliarella
Subs: Storari, Caceres, Pogba, Pepe, Giovinco, Giaccherini, Matri
Chelsea starting XI (5-2-3): Cech; Azpilicueta, Ivanovic, Luiz, Cahill, Cole; Mikel, Ramires; Mata, Oscar, Hazard
Subs: Turnbull, Bertrand, Romeu, Marin, Torres, Piazon, Moses