The Italy striker scored in the 4-0 win over FC Nordsjaelland on Wednesday night, leaving the Serie A champions third in Group E and needing to win at least one of their final two matches to have a realistic chance of qualification.
The 29-year-old also scored at Stamford Bridge earlier in the competition, and he believes the reverse fixture in Turin could be the Bianconeri's best chance of picking up all three points and reaching the last 16.
"Chelsea and Shakhtar are two great teams. Shakhtar have made a big impression on me and it won’t be easy to go and play in the Ukraine,” he explained to Sky Sport Italia.
“But the crucial game will be Chelsea at home. We have to do all that we can to get the victory in that one.
“Chelsea are a very physical and technical side. They are the reigning champions and we will have to be good at starting the game in the right way.”
The win over over the Norwegian side will give Antonio Conte's team a boost after losing their 49-match unbeaten run to Inter on Saturday.
But, the former Udinese man believes the Nerazzurri will now be a considerable threat for domestic honours this season.
"Inter have some great players and they are a team who will fight for the Scudetto, along with Napoli. I think that it will be a beautiful and exciting championship until the very end."