The Bundesliga champions recorded a 2-1 home win over the Blancos last month, and Hummels expects Jose Mourinho's side to be fired up and get their own back on the Schwarzgelben.
"I'm sure they'll want to get revenge and that's a fantastic challenge," Hummels was quoted as saying by news agency EFE.
"I don't know what to expect and what will be waiting for us at the Santiago Bernabeu, but without a doubt the atmosphere will be fantastic."
|6/1||Borussia Dortmund are 6/1 with bet365 to beat Real Madrid at the Bernabeu|
"They'll be annoyed because of their loss in Dortmund, and they'll try to roll over us. We're going to resist hard though," he stated.
Jurgen Klopp's men currently hold a one-point lead over Tuesday's opponents at the top of Group D.