The French midfielder is the only alteration to the Gunners side that lost 1-0 to Norwich City in the Premier League, as they face a German team led by striker Klaas-Jan Huntelaar
The swap of one Frenchman for another is Arsene Wenger's only alteration from the team who lost 1-0 to Norwich City in limp fashion on Saturday.
Aaron Ramsey moves to the right wing to accommodate his team-mate, with Lukas Podolski on the left and Gervinho leading the line as he did in the Gunners' previous Champions League tie, which they won against Olympiakos.
Klaas-Jan Huntelaar leads the line, as expected, for the visiting Bundesliga outfit, while Lewis Holtby, a transfer target for Liverpool, starts in a midfield also containing Barcelona loanee Ibrahim Afellay.
Arsenal starting XI: Mannone; Jenkinson, Mertesacker, Vermaelen, Andre Santos; Arteta, Coquelin; Ramsey, Cazorla, Podolski; Gervinho
Subs: Shea, Koscielny, Giroud, Djourou, Arshavin, Chamakh, Gnabry
Schalke starting XI: Unnerstall; Uchida, Matip, Howedes, Uchida; Neustadter, Hoger; Farfan, Holtby, Afellay; Huntelaar
Subs: Hildebrand, Marica, Jones, Barnetta, Moritz, Draxler, Kolasinac