Sir Alex Ferguson has made six changes to the team that beat Wigan at the weekend, with David de Gea returning in goal and Jonny Evans replacing Rio Ferdinand in defence
Shinji Kagawa and Robin van Persie have shaken off the knocks that prevented them from starting, while Patrice Evra and David De Gea return to the side in place of Alexander Buttner and Anders Lindegaard respectively.
Jonny Evans replaces Rio Ferdinand in defence, and Ryan Giggs makes way for Antonio Valencia. Rafael and Nemanja Vidic remain in central defence, and Paul Scholes, Michael Carrick and Nani all retain their places in midfield.
There's a number of familiar faces in the Galatasaray starting XI, including ex-Arsenal fullback Emmanuel Eboue, but former Bolton striker Johan Elmander has to make do with a spot on the bench.
Manchester United starting XI: De Gea; Rafael, Evans, Vidic, Evra; Valencia, Carrick, Scholes, Nani; Kagawa, Van Persie
Subs: Lindegaard, Ferdinand, Anderson, Chicharito, Welbeck, CLeverley, Fletcher
Galatasaray starting XI: Muslera, Dany, Hakan Balta, Semih Kaya, Eboue, Hamit Altıntop, Selcuk Inan, Felipe Melo, Amrabat, Burak, Umut
Subs: Ufuk Ceylan, Cris, Aydın Yılmaz, Riera, Engin Baytar, Emre Colak, Elmander