The France midfielder is now a major doubt for Sunday's Premier League clash with former club Arsenal after he was withdrawn in the first half of the Champions League clashSamir Nasri has limped out of Manchester City's Champions League tie against Real Madrid at the Santiago Bernabeu with a suspected hamstring injury.
The French midfielder was withdrawn before half-time, with the scores at 0-0, and replaced by Aleksandar Kolarov after being helped from the pitch while clutching his right hamstring.
He could now be set to miss the encounter with his former club Arsenal on Sunday.
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Nasri's start in Spain was his 51st appearance for Roberto Mancini's side.