The Premier League champions are embarking on only their second Champions League campaign and were knocked out of last season's competition at the group stage, along with bitter rivals Manchester United.
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“I was never on the winning side against them so let’s hope with City we can beat them," he told the Daily Express.
“It will be difficult. Right now Real and Barcelona are among the best teams in the world, but we have a great team too.”
Aguero will be hoping to play a part in the clash, having been out since mid-August with a knee injury which caused him to miss Argentina's two recent world cup qualifiers.