The Dutchman will orchestrate play as the Nerazzurri aim to reverse their one-goal deficit and reach the last eight of the tournament at the expense of the French outfit
The Italian side, who trail 1-0 from the first leg, have set out an attacking XI in the hope of getting the goals they need to progress, having restored some confidence into the camp after their win over Chievo last Friday.
Visiting coach Didier Deschamps has been able to significantly strengthen his starting XI since Friday night's shock reverse against Ajaccio. Most notably, the offensive trio of Loic Remy, Andre Ayew and Mathieu Valbuena are all fit again after recent injury problems, with the central striker featuring in the starting XI for the first time in almost exactly a month.
Souleymane Diawara has earned a recall into les Phoceens' defence, while Alou Diarra will act as a midfield pivot for the Ligue 1 side, who have failed to score in the their last four outings.
Inter: Julio Cesar; Maicon, Lucio, Samuel, Nagatomo; Poli, Zanetti, Stankovic; Sneijder; Forlan, Milito
Subs: Castellazzi, Ranocchia, Faraoni, Cambiasso, Obi, Pazzini, Zarate
Marseille: Mandanda; Azpilicueta, Diawara, N'Koulou, Morel; Diarra, Mbia; Valbuena, Amalfitano, A. Ayew; Remy
Subs: Bracigliano, Traore, Fanni, Cheyrou, Kabore, Brandao, J. Ayew